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Generic Name: Pizotifen 0.5mg
Manufacturer/Distributor: Acme Laboratories Ltd.
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✅ Description:
Indications
Pizotifen is used to treat vascular headaches of the migraine type, such as classical migraine, common migraine, and cluster headache, as a preventative measure. It is ineffective in stopping migraine attacks after they have started.
Pharmacology
Pizotifen works by repressing the fringe activities of serotonin and histamine in expanding the film porousness of cranial vessels and transudation of playmaking, whereas modifying torment limits headaches. By blocking 5-HT receptors, pizotifen constricts the flagging of serotonin causing cranial vasoconstriction, as well as serotonin-enhanced platelet work and accumulation. There's proof that it too hinders the fringe activities of bradykinin. Pizotifen may repress serotonin reuptake by blood platelets, which influences the tonicity and diminishes inactive distension of extracranial supply routes. The impacts of pizotifen driving to craving incitement may be due to the medication acting at the metabolic level instead of a coordinated incitement of the craving center.
Dosage & Administration
Adults: Usually 1.5 mg daily. This may be taken as a single dose at night or in three divided doses. Dosage should be adjusted to the individual patient requirements up to a maximum of 4.5 mg daily. Up to 3 mg may be given as a single dose.
Children (aged over 2 years): Up to 1.5 mg daily, usually as a divided dose, although up to 1 mg has been given as a single dose at night.
Interaction
Pizotifen may augment the central effects of sedatives, hypnotics, antihistamines (including several common cold remedies), and alcohol. The hypotensive impact of adrenergic neuron blockers is counteracted by pizotifen.
Contraindications
Patients who have a known hypersensitivity to any of the components in pizotifen should not use it.
Side Effects
The most prevalent negative effects include appetite stimulation, weight gain, and tiredness.
Pregnancy & Lactation
The use of Pizotifen during pregnancy is unknown, however, no adverse consequences have been observed. As a result, the medicine should only be used during pregnancy if the potential benefit to the mother outweighs the danger to the fetus. Pizotifen has not been proven to be safe during nursing, thus mothers should avoid taking it during breastfeeding.
Precautions & Warnings
Renal impairment and urinary retention should be considered. Drowsiness can impair your ability to drive a car or operate machinery. Pizotifen boosts the effects of alcohol.
Storage Conditions
Keep away from light and heat in a dry location. Keep out of children's reach.
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